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excessive weight loss

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Avoid excessive weight loss with strong CYP3A4 inhibitors with (increases cobimetinib systemic exposure by 6. Coadministration of conivaptan with strong CYP3A4 inhibitors is contraindicated. Coadministration of flibanserin with moderate or strong CYP3A4 inhibitors excessive weight loss contraindicated.

Severe hypotension or syncope can occur. Coadministration of ivabradine excessive weight loss strong CYP3A4 inhibitors is contraindicated. Increases lomitapide levels several folds.

Lonafarnib is a sensitive CYP3A4 substrate. Coadministration with strong or moderate CYP3A4 inhibitors is contraindicated. Coadministration of lurasidone and strong CYP3A4 inhibitors is contraindicated. Strong CYP3A4 inhibitors increase regorafenib levels and decrease exposure of the active metabolites M-2 and M-5. Increased risk for rhabdomyolysis with drugs that increase simvastatin systemic exposureketoconazole increases toxicity of simvastatin by Other (see comment).

Comment: OATP1B1 inhibitors may increase excessive weight loss of myopathy. Use of strong CYP3A4 inhibitors is contraindicated with venetoclax during the initial ramp-up dosing phase. Ketoconazole increases abemaciclib AUC by up to 16-fold. Avoid coadministration of acalabrutinib with strong CYP3A inhibitors. If a strong CYP3A inhibitor must be used short-term (eg, up to 7 days), temporarily interrupt treatment with acalabrutinib.

Coadministration of alpelisib (BCRP substrate) with a BCRP inhibitor may increase alpelisib concentration, which may increase the risk of toxicities. If unable to avoid or use alternant drugs, closely monitor for increased adverse reactions. Coadministration wsight strong CYP3A4 excessive weight loss contraindicated. Avoid coadministration of avapritinib excessive weight loss strong CYP3A4 inhibitors.

After discontinuation of a strong CYP3A inhibitor, resume the brigatinib dose that was tolerated prior to initiating the strong CYP3A inhibitor. Coadministration of cabazitaxel with strong CYP3A4 inhibitors should be excessive weight loss. Avoid coadministration of cabozantinib with strong CYP3A4 inhibitors.

Resume previous dose 2-3 days after strong CYP3A4 inhibitor discontinued.

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