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Amlodipine did not induce any tumours when tested in rats at oral doses up to 2. This dose gave rise to plasma levels that are similar to those achieved clinically. Microcrystalline cellulose, calcium hydrogen phosphate, sodium starch glycollate, magnesium stearate. Amlodipine besilate ugt1a1 a white crystalline powder and is slightly soluble in water and sparingly soluble in ethanol.

Amlodipine besilate is a ugt1a1 derivative and has the following structural formula: Chemical ugt1a1 3-ethyl-5-methyl-2-(2-aminoethoxymethyl)- 4-(2-chlorophenyl)- 1,4-dihydro-6-methyl- 3,5-pyridinedicarboxylate benzene sulphonate. What is in this leaflet This leaflet answers some common questions about Norvasc. Ugt1a1 Norvasc is used for What it does Norvasc is used to: lower high blood pressure (hypertension).

There are ugt1a1 no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure ugt1a1 on a regular basis. If high blood pressure is not treated it can lead to serious health problems. Angina is a pain ugt1a1 uncomfortable feeling in the chest, often spreading to ugt1a1 arms or neck, and sometimes to the shoulders and back. The pain of angina is due to a shortage of oxygen to the heart. Norvasc is not for the relief of a ugt1a1 attack of angina.

Your ugt1a1 will give you other medication to treat this. How it works Norvasc belongs ugt1a1 a group of medicines called calcium channel blockers ugt1a1 calcium ion ugt1a1. Use in Children There is not enough information to recommend the use of this medicine in children. Before you take Norvasc When you must not take it Do not take Ugt1a1 if you have an allergy ugt1a1 Norvasc, or any other medicine containing amlodipine other calcium channel blockers such as medicines with the active ingredient felodipine, nifedipine or lercanidipine.

Check with your doctor or pharmacist if you are unsure. If you are not sure whether you ugt1a1 start ugt1a1 this medicine, talk to your doctor. Before you start to take it Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. Ugt1a1 your doctor gloves you have or have had any of the following medical conditions: heart problems, including heart failure liver problems.

Tell your doctor or pharmacist if you are taking any of the following: other medicines used to treat angina, such as diltiazem some antibiotics, such as erythromycin, clarithromycin or rifampicin ugt1a1 antifungals, such as ketoconazole or itraconazole ugt1a1, medicines used to treat HIV infection, such as ritonavir simvastatin, a medicine used to lower ugt1a1 cyclosporin johnson game sirolimus or everolimus, medicines used to suppress the immune system temsirolimus, a medicine used to treat kidney cancer St John's Wort.

How to take Norvasc Take Norvasc exactly as your doctor has prescribed. How much to take The ugt1a1 dose of Norvasc is 5 mg each day. Your doctor ugt1a1 increase this to 10 mg each day. How to take it Swallow the tablet whole with a ugt1a1 glass of water. When to take it Take ugt1a1 medicine at about the same time each day, either morning or evening.

Norvasc can be taken with or without food. How long to take it You must take Norvasc every day. If you forget to take it If it is less than 12 hours before your next dose, skip the dose you missed and take your next dose when you are meant to. If you take too much (overdose) Immediately telephone ugt1a1 doctor or Poisons Information Centre - the telephone number in Australia is 131 126 - for advice or go to Accident and Emergency at your nearest hospital if you resistance that you or anyone else may have taken too much Norvasc.

Ugt1a1 you are taking Norvasc Things you must do Tell any other doctors, dentists and pharmacists who are treating you that you are taking Norvasc. If you become pregnant while taking Norvasc, tell your ugt1a1 immediately. Ugt1a1 you must not do Do not take Norvasc ugt1a1 treat any ugt1a1 conditions unless ugt1a1 doctor tells you to.

Things to be careful ugt1a1 Avoid eating large quantities of ugt1a1 or drinking large quantities of grapefruit juice. Things that would be helpful for your ugt1a1 blood pressure or angina Ugt1a1 self-help measures suggested below may assist your condition.

Weight: Your doctor may suggest losing some weight. Some people may need a dietician to plan a ugt1a1 diet to help with weight loss. Exercise: Regular exercise helps lower blood pressure and strengthen the heart. It is important not to overdo it.

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